Marijuana Use Research Study

Research Center: Medical University of South Carolina
Location: Roper Medical Office Building, 125 Doughty St, Suite 190
Lead Researchers: Dr. Aimee McRae-Clark, Dr Michael Saladin
Ethics Committee: This material has been reviewed and approved by the MUSC ethics committee.


With the growing legalization of cannabis use in the United States, researchers anticipate an increased need for informed, evidenced based treatments to help support those who have symptoms of use disorder. The study is specifically exploring gender differences in cannabis users regarding stress response, cannabis craving and withdrawal, and how the hormone progesterone may affects these areas.

While the study is not treatment, researchers hope to inform future treatments and how methods can potentially be specifically tailored for men and women. Participating in this study may help to develop ways to support those with substance use disorder.

Progesterone is a naturally occurring sex hormone involved in the menstrual cycle and reproduction, and has been shown to reduce withdrawal symptoms when people stop using substances like cocaine and nicotine. In this study the version of progesterone being utilized is biologically identical to natural progesterone hormone.

This study seeks men and women between the ages of 18 and 45 who frequently use marijuana. Participants are asked to attend 4 study visits over 1 month and to complete tasks at home over the course of 21 days. Participants are paid for each part of the study they complete.

Why Participate?

  • You may be helping to improve future treatment options for Cannabis Use Disorder.
  • You will be helping to advance medical research.

Your Rights

  • If you decide to participate in the study and later feel that you no longer wish to be part of it, you may withdraw at any time.
  • Your records relating to this study and any other information received will be kept strictly confidential, except as required by the law.
  • Qualified health professionals will monitor your health as it relates to the study.

Who Can Participate?

  • Men and women between the ages of 18 and 45 years old.
  • Use marijuana regularly (at least 5 times a week on average).
  • Able to attend 4 visits at the study site in Charleston, South Carolina within a period of approximately 1 month.

What’s Next?

  1. Click the link below to enter your contact details and answer some eligibility questions.
  2. The research centre will then contact you by phone to discuss the trial and answer your questions.
Click Here to Enter Your Contact Details and Be Contacted by Phone About the Study