Can Restrictive Eating Improve Memory Function? Find Out in This Study

Research Center: Iowa State University
Location(s): This is a remote study with optional in-person MRI visits
Lead Researchers: Dr. Auriel Willette and Dr. Steven Anderson
IRB Committee: This study has been reviewed and approved by the University of Iowa Institutional Review Board


Problems with blood sugar metabolism can progressively develop through old age, which is primarily due to obesity and lack of physical activity. It negatively impacts memory and brain functions and may lead to the development of mild cognitive impairment (MCI), a precursor to Alzheimer’s disease. 

Investigators in this study wish to engage participants with Mild Cognitive Impairment in a diet plan including intermittent calorie restriction (CR) – a form of restricted diet – to improve glucose metabolism. This results in reliable weight loss which in turn may improve memory and brain function in these individuals.

This study seeks men and women who currently suffer from memory problems. Participants are required to attend 8 study visits at the research site over an 18-week period and will be compensated up to $150 for participating in this study.

Why Participate? 

  • You may experience an improvement in your memory function.
  • You may experience weight loss.
  • You will be compensated $150
  • for participating in this study.
  • You will be helping to advance medical research.

Your Rights

  • If you decide to participate in the study and later feel that you no longer wish to be part of it, you may withdraw at any time.
  • Your records relating to this study and any other information received will be kept strictly confidential, except as required by law.
  • Qualified health professionals will monitor your health as it relates to the study.

Who Can Participate?

  • Men and women aged 60-85 who have concerns about their memory.
  • Can fast overnight for 8 hours ideally, or at least for 4 hours
  • Are able to undergo MRI scans (please note these visits are optional)
  • Able to attend 8 study visits at the research site over approximately 18 weeks.
  • Non-smokers
  • Have not been diagnosed with a mood or anxiety disorder

What Next?

  1. Click the link below to enter your contact details and answer some eligibility questions.
  2. The research centre will then contact you by phone to discuss the trial and answer your questions.
Click Here to Enter Your Contact Details and Be Contacted by Phone About the Trial