Depression Research Study Seeks Veterans

Please note: This trial has finished recruiting and is not accepting new participants.

Research Center: Michael E. DeBakey VA Medical Center
Location: 2002 Holcombe Blvd, Houston, TX 77030, USA
Lead Doctor: Sanjay J. Mathew, M.D
IRB Committee: This study has been reviewed and approved by Baylor College of Medicine Institutional Review Board


There is a critical public health need to identify rapidly-acting and safe treatments for veterans with severe and medication-resistant depressive disorders. This need is most acute among elderly veterans. It is estimated that by 2030, more than 20% of the US population will be 65 or older, a large portion of whom are represented by our Vietnam veterans. Major depressive disorder (MDD) is the most prevalent psychiatric disorder in individuals over 65 years of age, affecting up to 20% of the population.

The Michael E. DeBakey VA Medical Center is conducting a research study to determine the benefits of Ketamine for veterans who have treatment resistant late-life depression.

This study seeks men and women who are military veterans and currently suffer from depression. Participants are required to attend study visits at the research site over approximately 5 weeks and will be compensated up to $1,000 for travel and time away from work.

Why Participate?

  • You may experience an improvement in your depression symptoms.
  • You will receive a Ketamine treatment to potentially help your symptoms.
  • You will be compensated up to $1,000 for travel and time away from work.
  • You will be helping researchers better understand the best options for treating depression in older adults.
  • You could help find a new potential option for those older adults who are resistant to current antidepressant treatment.
  • You will be helping to advance medical research.

Your Rights

  • If you decide to participate in the study and later feel that you no longer wish to be part of it, you may withdraw at any time.
  • Your records relating to this study and any other information received will be kept strictly confidential, except as required by law.
  • Qualified health professionals will monitor your health as it relates to the study.

Who Can Participate?

  • Military veterans, 55 years of age or older
  • Are currently suffering from major depression
  • Have had previous or recurrent major depressive disorder for the last two years
  • Have not had relief from current or previous antidepressant treatments
  • Able to attend the study visits throughout the study.

What Next?

  1. Click the link below to enter your contact details and answer some eligibility questions.
  2. The research centre will then contact you by phone to discuss the trial and answer your questions.
Click Here to Enter Your Contact Details and Be Contacted by Phone About the Trial