Please note: This trial has finished recruiting and is not accepting new participants.

Research Center: Yale University
Location: New Haven, CT 06519, United States
Lead Researcher: Dr. Suchitra Krishnan-Sarin, Ph.D.
IRB Committee: This study has been reviewed and approved by the Yale University Institutional Review Board [IRB: 2000023077, 2000026248, & 2000025687]

Can e-cigarettes help people stop smoking? E-cigarettes are handheld devices that allow users to inhale nicotine in a vapor. Some people use e-cigarettes to stop cigarette smoking , but more research is needed to see if doing so is effective.  

This research study aims to understand how different flavors can make e-cigarettes more attractive. The results of this study may help lawmakers understand and decide what type of e-cigarettes should be sold in communities and whether or not they will help people to stop smoking cigarettes.

• Participants will be given an e-cigarette to use throughout the study, while they are at the research site.
• Participants will be compensated up to $575 for participating in this study. An additional compensation of $25 may also be received for each friend a participant refers to participate in the study.  
• Participants will be helping to advance medical research on e-cigarettes.
• Participants can opt to join other research studies on smoking that are conducted by the research center if they find that they are not eligible for this study or if they want to participate while they wait for a spot in this study to open.
• After completing the study, participants will be given information about the potential risks of continued smoking and will be provided with encouragement to think about changing their tobacco use behaviors.

• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Any information that you provide will be kept strictly confidential, except as required by law.
• Qualified health professionals will monitor your health as it relates to the study.

• Men and women aged 21+ who smoke daily
• People who have vaped e-cigs recently
• Must be willing to use e-cigarettes during study visits
• Must not be currently seeking treatment to stop smoking or plan to stop using e-cigarettes
• Must be able to attend 1 remote visit, 1 brief (10-minute) in-person visit, 4 study visits at the research site, and 2 brief phone follow-up appointments 

The study team can explain the research study in its entirety but some study details are:

• Study sessions will last for approximately 1-3 hours (depending on the session) and there will be a minimum of 24 hours between each session. 
• Participants can opt to join other research studies on smoking that are conducted by the research center if they find that they are not eligible for this study or if they want to participate while they wait for a spot in this study to open.
• Once enrolled in the study, participants will be asked to stop using all tobacco products (e.g. cigarettes and e-cigarettes) and marijuana for 12 hours prior to each lab session. 
• The e-cigarette provided to participants will contain nicotine and a different flavor for each session. E-cigarettes will be sanitized between sessions. 
• Participants will be asked to complete 30-minute follow-up appointments via telephone, 1 month and 6 months after their last session.
• Participants can opt to join other research studies on smoking that are conducted by the research center if they find that they are not eligible for this study, if they want to participate while they wait for a spot in this study to open, or after completing this study.

Yale University
Since its founding in 1701, Yale has been dedicated to expanding and sharing knowledge, inspiring innovation, and preserving cultural and scientific information for future generations. Yale is committed to improving the world today and for future generations through outstanding research and scholarship, education, preservation, and practice.

Please note:

Due to the current situation with the COVID-19 pandemic, the researchers would like to assure the participants that ensuring the safety of the participants as well as the study staff is of utmost importance.