Research Center: Purdue University
Location: A.H. Ismail Center for Preventive and Lifestyle Medicine
Lyles-Porter Hall, 715 Clinic Dr, West Lafayette, IN 47907
Lead Researcher: Dr. Chad C. Carroll
IRB: This study has been reviewed and approved by the Purdue Institutional Review Board

Are you interested in advancing the science of tendon health? Purdue University researchers are conducting a groundbreaking study to explore how blood markers may influence tendon properties in healthy adults. This study aims to uncover valuable insights into tendon degeneration and healing in healthy populations.

Why does this matter? By understanding how tendons change and adapt, researchers hope to develop better ways to predict, diagnose, and treat tendon-related conditions. The findings could pave the way for healthier, stronger tendons for everyone, now and in the future.

If you’re 40 or older, consider being part of this important study. Together, we can help shape the future of tendon health research!

• Participants may help advance research that may lead to the development of new treatment options for people with tendon problems.
• Participants will be compensated up to $75 for participating in this study. In the event of withdrawal from the study, compensation will be prorated based on the number of visits completed. 
• Participants will be contributing valuable information that may advance research on tendon health.
• Participants will be helping to advance medical research.

• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Any information that you provide will be kept strictly confidential, except as required by law.

• Men and women aged 40 and above
• Must not be pregnant or breastfeeding
• Must not have undergone knee replacement surgery or had an anterior cruciate ligament (ACL) injury (or similar knee procedure)
• Must be able to attend 5-6 study visits at the research site over approximately 1-2 months (4-6 weeks)
• Must not be individuals who have been diagnosed by a physician with liver disease
• Must not be chronic users of NSAIDs and or cyclooxygenase (COX) inhibitors

The study team will explain the research in its entirety but some details are:

• Participants will be asked to fill out and sign a consent form and medical history form, as well as complete a short survey on tendon pain.
• Participants will be asked to follow a 12-hour fast and undergo a blood sample collection.
• Participants will be asked to have patellar tendon assessments, including ultrasound measurements, familiarization with testing procedures, seated strength tests with ultrasound recording, and a patellar tendon strength assessment. Tendon strength assessments will be conducted with participants seated in a rigid chair with the knee joint at 90 degrees of flexion, monitored by an ultrasound probe during maximal efforts. Additionally, an MRI assessment will involve collecting scans of the patellar tendon (knee) and measuring the size of the knee tendon and thigh muscle using MRI.

Purdue University
Purdue University is a major research institution known for discoveries in science, technology, engineering, math, and beyond. Founded in 1869, the university proudly serves its state as well as the nation and the world. More than 37,000 students from all 50 states and 130 countries, along with some 850 student organizations and Big Ten Boilermaker athletics, make for a lively environment. 

Purdue University and Trialfacts are not affiliated. 
Trialfacts collaborates closely with the research team to facilitate a smooth flow of participant recruitment for this study at Purdue. Trialfacts operates as an advertising company to promote the study, while Purdue will be the organization that takes overall responsibility for eligible participants and addresses any questions or concerns that may arise.