This study is recruiting at sites in Sydney, Melbourne, Perth and Brisbane. For full details on each location, please read through and you will find the details below.

What happens when sex starts to feel more stressful than intimate? For many couples, lifelong premature ejaculation creates distance, frustration, and silence where there should be connection.

Researchers are exploring a potential on-demand treatment that aims to change that, supporting men with better control and helping both partners feel closer, more confident, and more understood. The goal isn’t just better sex; it’s better connection, confidence, and care.

If this hits home, now’s the time to step forward and help rewrite the story. Read on to learn more.

• Participants will take part in two treatment periods, one in which they will receive a potential new treatment, and one in which they will receive a placebo, at no cost, as part of a study exploring on-demand options for lifelong premature ejaculation.
• Compensation will be provided for each clinic visit, and travel-related expenses will be reimbursed (varies by location).
• Participants will follow a guided plan that may offer insight into their sexual health. Some may notice improvements in control and confidence.
• Every participant plays a key role in advancing research, helping shape better care options for others facing similar challenges.

• You will receive a detailed outline of the study, including treatment, risks, and procedures, and you will be given the chance to ask study staff questions before you decide whether to participate.
• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Your records relating to this study and any other information received will be kept strictly confidential, except as required by the law.

This study may be a good fit if you are:

• Men aged 18 to 65 who have been diagnosed with lifelong premature ejaculation (LPE) – premature ejaculation that has been present since the first sexual experience, and occurs within 1 minute of penetration, the majority of the time
• Must be in a stable, monogamous heterosexual relationship for at least 6 months – your partner will also need to consent to support you in the study
• Must be willing to follow the study requirements, including attempting intercourse regularly and using the study treatment as directed
• Must be able to attend multiple study visits at the research site over approximately 4-5 months

This study may not be suitable for individuals who:

• Men with other sexual dysfunctions or serious medical conditions (e.g., erectile dysfunction, heart disease, untreated thyroid issues, recent stroke, or cancer)
• Those who have used certain medications or treatments (like SSRIs, tramadol, Botox for Premature Ejaculation, or other Premature Ejaculation therapies) in the last 4 weeks; however, if you are willing to stop other Premature Ejaculation treatments for 4 weeks, you may then be able to take part
• Those currently participating in another clinical trial, or who have done so in the last 4 weeks
• Those with a recent history of drug use, severe mental health conditions, or severe allergies to medications

This study has been reviewed and approved by Bellberry and UnitingCare Health Human Research
Ethics Committee

Wesley Research Institute
Location: Level 8, East Wing, The Wesley Hospital, 451 Coronation Drive, Auchenflower QLD 4066, Australia
Principal Investigators: Professor Eric Chung and Dr. Jennifer Schafer

Keogh Institute For Medical Research
Location: 1st Floor. C Block., QEII Medical Centre, Hospital Avenue. Nedlands WA 6009
Principal Investigators: Professor Bronwyn Stuckey and Dr. Peter Burke

Momentum Darlinghurst, Sydney
Location: Level 7, 26 College Street, Sydney NSW 2010
Principal Investigator: Professor Mark Bloch

Men’s Health Melbourne
Location: 233 Collins Street, Melbourne, 3000, Australia
Principal Investigator: Dr. Darren Katz