Research Center: Wayne State University
Location: John D Dingell VAMC, 4646 John R Street, Detroit, MI 48201
Lead Researchers: Dr. Jason Mateika and Dr. Rebecca Barok
IRB: This study has been reviewed and approved by the Wayne State University IRB

Are you struggling with both sleep apnea (OSA) and hypertension? The discomfort of CPAP treatment can be challenging. Researchers from Wayne State University are investigating intermittent hypoxia as a potential treatment. This approach, which involves fluctuating oxygen levels, could be a game-changer for individuals with sleep apnea, particularly those also dealing with hypertension.

Intermittent hypoxia might offer a more comfortable and effective alternative or addition to CPAP treatment. It has the potential to not only improve sleep apnea symptoms but also address associated conditions like hypertension. Join in exploring this innovative treatment option and potentially improve your sleep quality, exercise capacity, and overall well-being. If you’re looking for new ways to manage sleep apnea and hypertension, consider joining this study.

• Participants will receive a new potential treatment for sleep apnea and hypertension at no cost.
• Participants will be compensated for participating in this study.
• Participants may experience improvements in sleep quality, exercise capacity, and overall well-being.
• Participants will be contributing valuable information that may benefit those with sleep apnea and hypertension in the future.
• Participants will be helping to advance medical research.

• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Any information that you provide will be kept strictly confidential, except as required by law.
• Qualified health professionals will monitor your health as it relates to the study.

• People aged between 30 and 60 who have experienced Obstructive Sleep Apnea (OSA)
• Must not have any medical conditions other than hypertension and sleep apnea
• Must not binge drink alcohol or consume more than 14 alcoholic drinks per week
• Must be able to sleep without the use of melatonin (sleeping pills) or other sleep aids
• Must not be taking 2 or more blood pressure medications
• Must not work on a night shift schedule
• Must not have recently traveled across different time zones
• Must be able to attend 23 study visits at the research site over approximately 3 months

The study team will explain the research in its entirety but some visit details are:

• Participants will undergo testing for blood pressure and heart signals. Lung function measurements will be taken along with a physical exam, and questionnaires. Blood draws will be taken to measure biomarkers. Visit 1 will last for about 3 hours.
• Participants will take part in the Overnight Sleep Study, which will confirm the participant’s sleep apnea. This visit will include electrodes for brain waves, chest bands for breathing, and a nasal tube. This visit will last for about 10 hours.
• Participants will take part in a 24-Hour Blood Pressure Measurement – After visit 2, participants will take a blood pressure device home for 24-hour monitoring. Measurements will automatically be taken every 20 minutes, along with diary documentation, or lab visit if needed.

Wayne State University
Since 1868, Wayne State University has provided students with a world-class education in the heart of Detroit, one of the nation’s most exciting cities. Our accomplishments go beyond the classroom, impacting our community and contributing to a better state, nation and world. With over 24,000 students, 3,000 full-time faculty experts, 350+ academic programs, 300,000 alumni living and working around the world