Research Center: Joslin Diabetes Center
Location: Joslin Diabetes Clinical Research Center, 330 Brookline Ave., Stoneman 1, Boston, MA 02215
Lead Researcher: Maria Vamvini, MD
IRB: This study has been reviewed and approved by the Joslin Diabetes Center Institutional Review Board

Can exercise help the brain support long-term weight management? This study explores how high-intensity interval training (HIIT) affects brain activity after bariatric surgery.

Researchers want to understand how exercise may help prevent weight regain by changing how the brain responds to food and appetite. The goal is to meet sustainable, healthy weight goals without added medications or surgeries.

Curious if this study is right for you? Find out more and see if you qualify.

• Participants will have a personalized exercise program and work closely with an exercise physiologist to support long-term weight maintenance after bariatric surgery, at no cost.
• Participants may receive compensation for completing all study visits and activities. Payment is provided for each completed study visit and each week of exercise participation, with an additional bonus for completing at least 90% of exercise sessions.
• Compensation will be issued by check within 4–6 weeks after study completion. Free parking is available for in-person visits, and public transit fare may be reimbursed.
• Participants may experience improvements in weight maintenance and brain function related to appetite control.
• By participating, individuals contribute important insights into how exercise influences metabolism, mood, cognition, and appetite regulation after bariatric surgery.
• Participants play a vital role in advancing research on the metabolic and behavioral response to high-intensity exercise after bariatric surgery.

• You will receive a detailed outline of all details of the study, including treatment, risks, and procedures, and you will be given the chance to ask study staff questions before you decide whether to participate.
• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time
• Your records relating to this study and any other information received will be kept strictly confidential, except as required by the law.

Eligible:

• Men and women aged 18 to 70 who have previously undergone bariatric surgery
• Must have experienced significant weight regain (more than 10% of maximum weight lost) within 1 to 5 years after surgery, or be unsure about this
• Must be generally healthy and not regularly engage in more than 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity exercise per week
• Must be able and willing to share their weight history and provide their bariatric surgery operative report
• Must be able to attend 5 study visits at the research site over approximately 20 weeks

Ineligible:

• Individuals with active heart or lung disease, or a history of cardiovascular disease, stroke, or congestive heart failure
  Left-handed individuals
• Those who weigh more than 551 lbs (250 kg) or have a BMI less than 19 kg/m²
• Individuals who are unable or unwilling to provide necessary medical records or attend all required study visits.

Joslin Diabetes Center
Joslin Diabetes Center is at the forefront of research exploring how metabolism, exercise, and the brain interact to influence long-term health. Our goal is to translate these discoveries into strategies that enhance well-being and prevent disease.