Posttraumatic Stress Disorder (PTSD) doesn’t affect everyone the same way, and not every treatment works for everyone. Roughly 1 in 3 Veterans experience symptoms of PTSD. For many, finding relief is a long and frustrating journey.

The M-PACT Study is exploring a new approach that allows Veterans and Active-Duty service members to try multiple study medications, with the hope of finding something that truly helps.

If you’re a veteran or currently serving, aged 18 to 65, and living with PTSD, you may be eligible to participate. Before joining, you’ll go through a screening process to determine whether the study is appropriate and safe for you.

• Participants may receive new potential treatments for PTSD at no cost.
• Participants will be compensated up to $575 for participating in this study.
• Participants may experience improvements in symptoms related to PTSD.
• Participants will be contributing valuable information that may benefit society in the future.
• Participants will help advance medical research.

• You will receive information outlining all the details of the study, including treatment, risks, and procedures, and you will be given the chance to ask study staff questions before you decide whether to participate.
• You can leave the study at any time. Your usual care won’t be affected, and nothing is taken away if you choose not to participate. Joining the study is entirely up to you.
• Your records relating to this study and any other information received will be kept strictly confidential, except as required by the law.

Eligible:

• You are between 18 and 64 years old
• You are currently serving or have previously served in any branch of the U.S. military
• You have been diagnosed with PTSD (Posttraumatic Stress Disorder), and your symptoms started more than 3 months ago
• You are able to participate in study assessments, including blood draws and MRI scans
• You can attend all required study visits over approximately 4 months

Ineligible:

• You are pregnant, breastfeeding, or planning pregnancy during the study
• You are at high risk for suicide based on recent history, hospitalizations, or past reactions to psychiatric medications
• You have recently started or stopped trauma-focused therapy (within the last 3 months), or plan to stop during the study
• You have psychosis or other medical conditions that may interfere with the study
• You have a history of significant liver or kidney problems, abnormal lab results, or abnormal ECG readings
• You have participated in another treatment clinical trial within the last 3 months
• You are unlikely to be available or able to comply with study requirements

This research study is taking place in several locations. To see if there is a research site near you, please see below.

Research Site’s Logo:

Research Site: Cincinnati VA Medical Center
Location: 1000 South Ft. Thomas Ave., Ft. Thomas, KY 41075
Lead Researcher: Dr. Jacob Forrester, MD

This study has been reviewed and approved by the Advarra Institutional Review Board.