Research Studies For Those Who Struggle With Alcohol Use Disorder (AUD) Coupled with Post-Traumatic Stress Disorder (PTSD)

Research Center: Department of Psychiatry, NYU Langone Health
Location: 8th floor One Park Avenue between 32nd & 33rd Streets, New York, NY 10016
Lead Investigator: Charles Marmar, M.D.
IRB Committee: This study has been reviewed and approved by NYU Langone Health Institutional Review Board


Alcohol use disorder (AUD) has been found to frequently co-occur with post-traumatic stress disorder (PTSD). It is estimated that 30-60% of individuals who have alcohol use disorder (AUD) also have post-traumatic stress disorder (PTSD). Research has shown that there is a link between how the brain responds to negative emotions (which is common in PTSD) and addiction (which is common in AUD). 

Currently, two studies are recruiting to find the effectiveness of two investigational drugs on alcohol use disorder (AUD) coupled with post-traumatic stress disorder (PTSD). One study is exploring Cannabidiol (CBD, in pill form) and the other explores Topiramate as potential methods of care for AUD co-occurring with PTSD.

The studies seek adults aged 18 to 70 years old who are struggling with AUD co-occurring with PTSD. Participants are asked to attend all the necessary study visits. The CBD study will run for approximately 3 months while the topiramate study will run for approximately 4 months. 

Why Participate? 

  • You will help advance medical research.
  • You may experience improvements to your alcohol use disorder.
  • You may experience improvements to your post-traumatic stress disorder.
  • You may be able to better manage symptoms of AUD and PTSD. 
  • You will be compensated for participating in this study, ranging from up to $440 or up to $975 depending on the study you participate in and how many appointments you complete.
  • Reimbursement for travel, accommodation, and meals is available for in-person visits.
  • Qualified health professionals will monitor your health as it relates to the study.

Your Rights

  • If you decide to participate in a study and later feel that you no longer wish to be part of it, you may withdraw at any time.
  • Your records relating to the study and any other information received will be kept strictly confidential, except as required by the law.

Who Can Participate?

  • Adults aged 18 to 70 years old who are experiencing symptoms of stress after a traumatic event.
  • Must have the desire to cut down on drinking.
  • Must have at least 6 heavy drinking days in the past 30 days.
  • Must be able to attend the remote visits (through video or phone) and the in-person visits (at our office in midtown Manhattan) over approximately 3 months.