Please note: This trial has finished recruiting and is not accepting new participants.

Research Center: Endocrine Hypertension Research Center
Location: Clinical Research Facility Princess Alexandra Hospital, Woolloongabba, Brisbane
Lead Doctors: A/Professor James Sharman, Professor Michael Stowasser, Professor Walter Abhayaratna   
Ethics Committee: Reviewed and approved by Metro South Service Health Human Research Ethics and University of Queensland Human Research Ethics

Background

Did you know that high blood pressure (hypertension) is the most commonly avoidable cause of death from cardiovascular disease? The University of Queensland is continuing research that found much of this risk may be due to persistently elevated central blood pressure (the pressure in the arteries close to your heart).

A major breakthrough has shown that targeted therapy to reduce central blood pressure and risk from cardiovascular disease may be possible using a low dose of a common medication called spironolactone. This is being tested in this current study. If selected, participants will take spironolactone daily and the cardiovascular effects measured.

Benefits of Participation

• You will get a cardiovascular assessment including echocardiograph and MRI heart measures.
• You will have your blood pressure monitored over 2 years by doctors who specialize in hypertension.
• You and your treating doctor will receive all clinical information.
• You will be helping to advance medical research.

Your Rights

• Your records relating to this study and any other information received will be kept strictly confidential.
• Upon completion, the results of the study will be shared with you and your doctor.
• Qualified medical professionals will supervise your participation.
• You will be able to withdraw from the study at any time.

Who Can Participate?

• Men and women aged 18 to 70 years
• Have hypertension (high blood pressure) and are taking at least 1 but no more than 3 medications for blood pressure control.
• Are prepared to take the medication for the duration of the study
• Are prepared to have an MRI.