Research Center: UVA Health with Myriad Genetics
Location: This is a study recruiting in Virginia and Maryland
Lead Researcher: Dr. Jennifer L. Payne
IRB:This study has been reviewed and approved by the University of Virginia Institutional Review Board HSR230396

How does pregnancy affect the way antidepressants work? UVA Health is conducting a study to explore how Zoloft® (sertraline), a common antidepressant, is metabolized during pregnancy and during the postpartum period. This study aims to pinpoint when Zoloft®(sertraline) levels return to a pre-pregnancy state.

If you’re in your third trimester or a non-pregnant woman taking Zoloft® (sertraline), consider joining this study.  You can take part of this study from the comfort of your home or location of choice. Understanding the metabolism of Zoloft® (sertraline), may help healthcare providers offer more precise treatment plans.

• Participants will contribute information that may benefit those with depressive or anxiety disorders in the future.
• Participants will be helping to advance antidepressant metabolism research.

• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Any information that you provide will be kept strictly confidential, except as required by law.

• Women aged 18-44 years old, who have been taking Zoloft® (sertraline) as prescribed, with the last dose taken within the past 24 hours. You should have taken the medication regularly for the last three days and have been using it for depression and/or anxiety for at least seven days prior to enrollment. 
• For women in their third trimester of pregnancy (28-40 weeks), you must plan to continue taking Zoloft® (sertraline) during pregnancy and after delivery
• Must be able to participate from 2 to up to 5 tele-visits.
• Must be willing to be contacted by UVA study staff for follow-up appointments, complete electronic questionnaires, and be willing to have mobile phlebotomy (blood collection) personnel collect samples for the study in the comfort of your home or at a location of your choice

The study team will explain the research in its entirety, but some details are:

• Participants will be asked to provide demographic,medical history information, and pregnancy details, as applicable.
• Participants will be asked to collect and send blood samples (via self-administered blood collection device) and four cheek (buccal) swabs, which consists of two swabs taken on each side.
• Participants will be asked to complete medication logs, which can be done via email or phone with study staff.

UVA Health
At the University of Virginia School of Medicine, our mission is to transform health and inspire hope for all Virginians and beyond. Our vision is to be the nation’s leading public academic School of Medicine and the best place to work-while transforming patient care, research, education and management with the diverse communities we serve.