Research Center: Cedars Sinai Medical Center (CSMC)
Location: 8635 W 3rd St., Los Angeles, CA, 90048
Lead Researcher: Dr. Nicolas Musi
IRB: This study has been reviewed and approved by the Cedars Sinai Institutional Review Board

Did you know that maintaining a healthy lifestyle significantly reduces the risk of developing chronic cardiometabolic diseases? Conditions like type 2 diabetes, heart disease, and non-alcoholic fatty liver disease can be prevented or managed through healthy habits. While the exact mechanisms behind this connection remain unclear, scientists believe that various factors are involved in maintaining metabolic health.

That’s why researchers from Cedars Sinai Medical Center are conducting an exciting study to explore how senescent cells (cells that age and permanently stop dividing but do not die) may influence the body’s ability to process sugars. This study aims to delve into the cellular mechanisms within fat tissue to enhance our understanding of how aging impacts the health of adults over time. By doing so, we can accelerate the development of strategies to optimize metabolic outcomes and design personalized lifestyle programs for achieving long-term health and wellness.

• Participants will be compensated up to $450 for participating in this study. Compensation will only be provided to eligible participants who complete study visits.
• Participants may experience improvements in their health.
• Participants will be contributing valuable information that may benefit adults who are struggling with their health in the future.
• Participants will be helping to advance medical research on senescent cells.

• If you decide to participate in the study and later feel that you no longer wish to be part of it, you can withdraw at any time.
• Any information that you provide will be kept strictly confidential, except as required by law.
• Qualified health professionals will monitor your health as it relates to the study.

• Men and women aged 65 years old and above who have a BMI between 18.5 – 24.9 kg/m² and who exercise less than 1.5 hours weekly.
• Must NOT live in a nursing home.
• Must not have heart disease, peripheral vascular disease, diabetes, or pulmonary disease (e.g., COPD, severe asthma, or exercise-induced asthma).
• Must not have uncontrolled blood pressure, a history of stroke with motor disability, acute or chronic infection, or active gastrointestinal disease.
• Must not be currently smoking, have a history of alcohol or substance abuse, or have had bariatric surgery.
• Must be able to attend 4-5 study visits at the research site over approximately 4 weeks.

The study team will explain the research in its entirety, but some details are:

• Participants will be asked to take physical examinations, blood and urine laboratory assessments, anthropomorphic measurements (height, weight, BMI), physical activity/dietary assessment, insulin-resistance testing and adipose (fat) tissue biopsies, oral glucose tolerance test (OGTT), DEXA scans to measure fat and muscle mass, and electrocardiogram, and exercise capacity tests.

Cedars Sinai Medical Center (CSMC)
Cedars-Sinai is a nonprofit academic healthcare organization serving the diverse Los Angeles community and beyond. With pioneering medical research achievements, education programs defining the future of healthcare, and wide-ranging community benefit activities, Cedars-Sinai is setting new standards for quality and innovation in patient care.

Please note:
Due to the COVID-19 pandemic, the researchers would like to assure the participants that ensuring their and the study staff’s safety is of utmost importance.